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科技人才

刘可春

时间:2015-10-29 15:00:00  来源:  作者:

刘可春,博士,研究员,生物研究所 所长 

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    个人简介

    刘可春,男,1964年11月出生,博士,研究员。1989山东大学生物系生物化学硕士毕业,2006年山东中医药大学中药学博士毕业。现任澳门金沙官方游戏所长,山东省生物检测技术工程实验室主任、山东省人类疾病斑马鱼模型与药物筛选工程技术中心主任、中国实验动物学会水生实验动物专业委员会副主任委员、中国药学会海洋药物专业委员会委员、山东省药学会中药与天然药物专业委员会委员、生化与生物技术药物专业委员会委员、山东省实验动物学会常务理事、山东省毒理学会常务理事、《山东科学》编委、药理与毒理专栏主持人、科技部项目评审专家。
    主要从事斑马鱼模型的建立及基于斑马鱼模型的药物活性毒性评价与新药的研发工作,于2006年建立了国内首个基于斑马鱼模型的药物筛选平台,在斑马鱼疾病模型的构建及药物早期成药性评价方面做了大量的开拓性研究工作,带领团队先后建立了包括肿瘤、心血管疾病、神经系统疾病等40多种人类疾病斑马鱼模型。
    先后主持承担国家、省部级项目二十多项,获得国家科技进步三等奖1项,省部级科技进步一等奖2项、二等奖1项、三等奖2项,国家发明创业奖人物奖1项,山东省发明创业一等奖1项;授权国家发明专利33项,实用新型专利16项,国外发明专利1项,发表科技论文100多篇,其中SCI收录50多篇。
    研究方向:药物筛选、药物早期成药性评价及药物与保健食品研发
    招生专业:生物学(疾病动物模型)、生物工程
    联系方式:0531-82605352   Email:
hliukch@sdas.org
    
     代表性论文(近五年):
1.Jin, M., Zhang, B., Sun, Y., Zhang, S., Li, X., Sik, A., Bai, Y., Zheng, X. & Liu, K*. Involvement of peroxisome proliferator-activated receptor gamma in anticonvulsant activity of alpha-asaronol against pentylenetetrazole-induced seizures in zebrafish, Neuropharmacology. 2020, 162, 107760.
2.Kechun Liu, Lizhen Wang & Zhongwu Guo. An extensive review of studies on mycobacterium cell wall polysaccharide-related oligosaccharides – part III: synthetic studies and biological applications of arabinofuranosyl oligosaccharides and their analogs, derivatives and conjugates. Journal of Carbohydrate Chemistry 2019, VOL. 38, NOS. 7–8, 414–469
3.Zhang, Y., Zhang, Y., Li, J., Chen, Y., Han, L., He, Q., Chu, J. &Liu, K*. The role of hepatic antioxidant capacity and hepatobiliary transporter in liver injury induced by isopsoralen in zebrafish larvae, Hum ExpToxicol. 2019,38, 36-44.
4.Bangeppagari Manjunatha, Liwen Han, Rajesh R. Kundapur, Kechun Liu*, Sang Joon Lee*. Herbul black henna (hair dye) causes cardiovascular defects in zebrafish (Danio rerio) embryo model. Environ Sci Pollut Res (2020). https://doi.org/10.1007/s11356-020-07762-z
5.Zhang, X. M., Han, L. W., Zhang, S. S., Li, X. B., He, Q. X., Han, J., Wang, X. M. & Liu, K. C*. Targeted discovery and identification of novel nucleoside biomarkers in Apostichopusjaponicus viscera using metabonomics, Nucleosides, nucleotides & nucleic acids. 2019,38, 203-217.
6.Zhang, X. M., Han, L. W., Sheng, W. L., Li, X. B., Zhang, S. S., Guo, J. L., Lin, H. W. &Liu, K. C*. Two novel non-holostane type glycosides from the viscera of sea cucumber Apostichopusjaponicus, Journal of Asian natural products research,2019, 1-9.
7.Zhang, S., Gao, Y., He, Q., Zhang, Y., Han, L., Jin, M., Liu, T., Liu, K*.& Sun, C. A new active peptide from Neptuneaarthriticacumingii exerts protective effects against gentamicin-induced sensory-hair cell injury in zebrafish, Drug and chemical toxicology, 2019,1-9.
8.Liao, S., Han, L., Zheng, X., Wang, X., Zhang, P., Wu, J., Liu, R., Fu, Y., Sun, J., Kang, X., Liu, K., Fan, T. P., Li, S. &Zheng, X. Tanshinolborneol ester, a novel synthetic small molecule angiogenesis stimulator inspired by botanical formulations for angina pectoris, British journal of pharmacology. 2019,176, 3143-3160.
9.Li, X., Zhang, B., Li, N., Ji, X., Liu, K*.& Jin, M. Zebrafish neurobehavioral phenomics applied as the behavioral warning methods for fingerprinting endocrine disrupting effect by lead exposure at environmentally relevant level, Chemosphere. 2019, 231, 315-325.
10.Li, T., Tang, X., Luo, X., Wang, Q., Liu, K., Zhang, Y., de Voogd, N. J., Yang, J., Li, P. & Li, G. Agelanemoechine, a DimericBromopyrrole Alkaloid with a Pro-Angiogenic Effect from the South China Sea Sponge Agelasnemoechinata, Organic letters. 2019, 21, 9483-9486.
11.Jiao, W. H., Li, J., Zhang, M. M., Cui, J., Gui, Y. H., Zhang, Y., Li, J. Y., Liu, K. C*.& Lin, H. W. Frondoplysins A and B, Unprecedented Terpene-Alkaloid Bioconjugates from Dysideafrondosa, Organic letters. 2019,21, 6190-6193.
12.Jia, Z. L., Cen, J., Wang, J. B., Zhang, F., Xia, Q., Wang, X., Chen, X. Q., Wang, R. C., Hsiao, C. D., Liu, K. C.& Zhang, Y. Mechanism of isoniazid-induced hepatotoxicity in zebrafish larvae: Activation of ROS-mediated ERS, apoptosis and the Nrf2 pathway, Chemosphere. 2019, 227, 541-550.
13.Huo, J., Yu, Q., Zhang, Y., Liu, K., Hsiao, C. D., Jiang, Z. & Zhang, L. Triptolide-induced hepatotoxicity via apoptosis and autophagy in zebrafish, J ApplToxicol. 2019, 39, 1532-1540.
14.Hu, Y. H., Yang, J., Zhang, Y., Liu, K. C., Liu, T., Sun, J. & Wang, X. J. Synthesis and biological evaluation of 3-(4-aminophenyl)-coumarin derivatives as potential anti-Alzheimer's disease agents, Journal of enzyme inhibition and medicinal chemistry. 2019, 34, 1083-1092.
15.Han, L., Xia, Q., Zhang, L., Zhang, X., Li, X., Zhang, S., Wang, L., Liu, C.& Liu, K*. Induction of developmental toxicity and cardiotoxicity in zebrafishembryos/larvae by acetyl-11-keto-beta-boswellic acid (AKBA) through oxidative stress, Drug and chemical toxicology, 2019, 1-8.
16.Han, J., Liu, K., Wang, R., Zhang, Y. & Zhou, B. Exposure to cadmium causes inhibition of otolith development and behavioral impairment in zebrafish larvae, AquatToxicol. 2019, 214, 105236.
17.Gui, Y. H., Liu, L., Wu, W., Zhang, Y., Jia, Z. L., Shi, Y. P., Kong, H. T., Liu, K. C., Jiao, W. H. & Lin, H. W. Discovery of nitrogenous sesquiterpenequinone derivatives from sponge Dysideaseptosa with anti-inflammatory activity in vivo zebrafish model, Bioorganic chemistry, 2019,103435.
18.Gui, Y. H., Jiao, W. H., Zhou, M., Zhang, Y., Zeng, D. Q., Zhu, H. R., Liu, K. C., Sun, F., Chen, H. F. & Lin, H. W. Septosones A-C, in Vivo Anti-inflammatory Meroterpenoids with Rearranged Carbon Skeletons from the Marine Sponge Dysideaseptosa, Organic letters. 2019,21, 767-770.
19.Zhang, Y., Cen, J., Jia, Z., Hsiao, C. D., Xia, Q., Wang, X., Chen, X., Wang, R., Jiang, Z., Zhang, L. &Liu, K*. Hepatotoxicity Induced by Isoniazid-Lipopolysaccharide through Endoplasmic Reticulum Stress, Autophagy, and Apoptosis Pathways in Zebrafish, Antimicrob Agents Chemother. 2019, 63.
20.Jin, M., Ji, X., Zhang, B., Sheng, W., Wang, R. &Liu, K*. Synergistic effects of Pb and repeated heat pulse on developmental neurotoxicity in zebrafish, Ecotoxicol Environ Saf. 2019,172, 460-470.
21.Jin, M., Xiao, Z., Zhang, S., Men, X., Li, X., Zhang, B., Zhou, T., Hsiao, C. D. &Liu, K*. Possible involvement of Fas/FasL-dependent apoptotic pathway in alpha-bisabolol induced cardiotoxicity in zebrafish embryos, Chemosphere. 2019, 219, 557-566.
22.Han, L., Sheng, W., Li, X., Sik, A., Lin, H., Liu, K*.& Wang, L. Novel carbohydrate modified berberine derivatives: synthesis and in vitro anti-diabetic investigation, Medchemcomm. 2019, 10, 598-605.
23.Zhang, Y., Zhang, Y., Li, J., Chen, Y., Han, L., He, Q., Chu, J. &Liu, K*. The role of hepatic antioxidant capacity and hepatobiliary transporter in liver injury induced by isopsoralen in zebrafish larvae, Hum ExpToxicol. 2019,38, 36-44。
24.Li, X., Zhang, B., Li, N., Ji, X., Liu, K*.& Jin, M. Zebrafish neurobehavioral phenomics applied as the behavioral warning methods for fingerprinting endocrine disrupting effect by lead exposure at environmentally relevant level, Chemosphere. 2019,231, 315-325.
25.Zhang, Y., Li, J., Chen, Y., Han, L., He, Q., Chu, J. &Liu, K*. The role of hepatic antioxidant capacity and hepatobiliary transporter in liver injury induced by isopsoralen in zebrafish larvae, Hum ExpToxicol. 2019,38, 36-44.
26.Zhang, Y., Li, S., Li, J., Han, L., He, Q., Wang, R., Wang, X. &Liu, K*. Developmental toxicity induced by PM2.5 through endoplasmic reticulum stress and autophagy pathway in zebrafish embryos, Chemosphere. 2018, 197, 611-621.
27.Xia, Q., Wei, L., Zhang, Y., Kong, H., Shi, Y., Wang, X., Chen, X., Han, L. &Liu, K*. Psoralen Induces Developmental Toxicity in Zebrafish Embryos/Larvae Through Oxidative Stress, Apoptosis, and Energy Metabolism Disorder, Front Pharmacol. 2018,9, 1457.
28.Li, X., He, Q., Hou, H., Zhang, S., Zhang, X., Zhang, Y., Wang, X., Han, L. & Liu, K*. Targeted lipidomics profiling of marine phospholipids from different resources by UPLC-Q-ExactiveOrbitrap/MS approach, J Chromatogr B AnalytTechnol Biomed Life Sci. 2018, 1096, 107-112.
29.Shan-Shan Zhang, Li-Wen Han, Yong-Ping Shi, Xiao-Bin Li, Xuan-Ming Zhang , Hai-Rong Hou, Hou-Wen Lin and Ke-Chun Liu*. Two Novel Multi-Functional Peptides from Meat and Visceral Mass of Marine Snail Neptunea arthritica cumingii and Their Activities In Vitro and In Vivo. Marine Drugs, 2018, 16, 47.
30.Li JJ, Zhang Y, Han LW, Tian QP, He QX, Wang XM, Sun C, Han J, Liu KC*. Tenacissoside H exerts an anti-inflammatory effect by regulating the nf-κb and p38 pathways in zebrafish. Fish Shellfish Immunol. 2018 Sep 11;83:205-212.
31.Jin M, Sheng W, Han L, He Q, Ji X, Liu K*. Activation of BDNF-TrkB signaling pathway-regulated brain inflammation in pentylenetetrazole-induced seizures in zebrafish. Fish Shellfish Immunol. 2018 Sep 6;83:26-36. doi: 10.1016/
32.Meng Jin, Qiuxia He, Shanshan Zhang, Yixuan Cui, Liwen Han*, Kechun Liu*. Gastrodin Suppresses Pentylenetetrazole-Induced Seizures Progression by Modulating Oxidative Stress in Zebrafish.Neurochemical Research. 2018,Volume 43:904–917。
33.Yu Zou, Yun Zhang, Liwen Han, Qiuxia He, Hairong Hou, Jian Han, Ximin Wang, Chengyun Li, Juan Cen*, Kechun Liu*. Oxidative stress-mediated developmental toxicity induced by isoniazide in zebrafish embryos and larvae. Journal of Applied Toxicology, 2017, 10.1002/jat.3432
34.Chao Zhang, Chuwen Li, Shenghui Chen,Zhiping Li, Xuejing Jia, Kai Wang, Jiaolin Bao, Yeer Liang, Xiaotong Wang, Meiwan Chen, Peng Li, Huangxing Su, Jian Bo Wan, Simon Ming Yuen Lee, Kechun Liu*, Chengwei He. Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways. Redox Biol. 2017,11, 1-11。
35.Wang X, Liu KC*, Sun GJ, Han LW, Wang RC, Peng WB, Sun C, Hsiao CD, Zhang Y, Hou HR. Evaluation of nephrotoxic effects of aristolochic acid on zebrafish (Danio rerio) larvae. Hum Exp Toxicol. 2016, DOI: 10.1177/0960327115613844
36.Yun Zhang, Liwen Han, Qiuxia He, Weiyun Chen, Chen Sun, Xue Wang, Xiqiang Chen, Rongchun Wang, Chung-Der Hsiao, Kechun Liu*. A rapid assessment for predicting drug-induced hepatotoxicity using zebrafish. Journal of Pharmacological and Toxicological Methods. 2016, DOI: 10.1016/j.vascn.2016.12.002
37.陈锡强,韩利文,王希敏,王荣春,侯海荣,刘可春*,彭维兵,孙 晨,韩建。人乳腺癌斑马鱼移植瘤模型建立。中国药理学通报. 2016,32(1):128-132.

    授权专利(近五年):
1. 王雪,刘可春,何秋霞,韩利文,张云,盛文龙,李晓彬,孙晨。一种斑马鱼老年疾呆模型的建立方法及应用。2020.01.21,中国,201810724850.4。
2. 韩利文,张姗姗,刘可春,李晓彬,张轩铭,侯海荣,孙晨。具有心脑血管保护功能的多肽及其制备方法与应用。2019.5.14,中国,ZL201810916171.7。
3. 张姗姗,刘可春,韩利文,张轩铭,李晓彬,张云。具有修复氧化损伤功能的多肽及其制备方法与应用。2019.8.9,中国,ZL201810915407.5。
4. 韩利文,张姗姗,何秋霞,刘可春,王莹,李晓彬,张轩铭,韩拥政,侯海荣,王希敏,王雪,郭敬兰,王丽娟。一种竹柳皮抗炎活性提取物的制备方法和应用。2019.9.27,中国,ZL201611103837.4。
5. 张姗姗,王荣春,何秋霞,韩利文,刘可春,王莹,韩拥政,王希敏,李晓彬,张轩铭,侯海荣,郭敬兰,王雪,王丽娟。一种竹柳抗氧化活性组分的制备方法和应用。2019.10.15,中国,ZL201611103795.4。
6. 王雪,刘可春,张云,韩利文,陈锡强,夏青,王荣春,王希敏。一种用于研究斑马鱼再生修复功能的装置。2019.09.27,中国,ZL201920216813.2。
7. 韩利文,刘可春,何秋霞,张云,韩建,王荣春,孙晨,王雪,侯海荣,彭维兵,陈维云。一种用于评价化合物对病理状态下血管生成作用的方法。 2018.04.24,中国,ZL2016106770273。
8. 张云,刘可春,韩利文,王雪,何秋霞,孙晨,王希敏,楚杰,韩建,王荣春。一种快速评价化合物对斑马鱼肝脏功能损伤作用的方法。2018.01.26,中国,ZL2015104871398。
9. 韩利文;刘可春; 何秋霞; 张云; 韩建; 王荣春;  孙晨; 王雪; 侯海荣; 彭维兵; 陈维云。一种用于评价化合物对病理状态下血管生成作用的方法。 2018.04.24,ZL2016106770273。
10. 何秋霞;刘可春;韩利文;楚杰;张云;王雪;王希敏;张珊珊。一种利用斑马鱼评价化合物急性毒性的装置及其工作方法。2018.05.18,中国,ZL2017101098091。
11. 张云;刘可春; 韩利文;  何秋霞; 王雪;  彭维兵;  陈维云; 王希敏; 侯海荣; 陈锡强。一种筛选具有保护斑马鱼肝功能活性化合物的方法。2018.07.24,ZL2015104867509
12. 王雪,刘可春,韩利文,陈锡强,何秋霞,彭维兵,王希敏,侯海荣,张云,孙晨,楚杰。一种通过检测斑马鱼组织肌酐含量评价化合物肾脏毒性的方法。2017.10.29,中国,ZL201410334259.X。
13. 王雪,刘可春,韩利文,孙晨,楚杰,彭维兵,陈锡强,何秋霞,张云,王希敏,侯海荣。一种筛选具有保护或改善肾功能活性化合物的方法。2018.11.12,中国,ZL201410377736.0。
14. 刘可春,韩利文,袁延强,何秋霞,王思峰,陈锡强。一种含异甘草黄酮醇的抗肿瘤药物及其应用。2015.4.22,中国,ZL2011103774405。

    主持承担的科研项目(近五年)
1. 国家重点研发计划项目,“基于生物效应和DNA 身份证的中成药质量控制技术研究及其应用”(2018YFC1707303),2018.12-2021.12,经费205万元,负责人。
2. 国家海洋公益性行业科研专项,“海产多不饱和脂肪酸磷脂规模化制备技术的研究及产业化示范”(201505030-2),2015.01~2018.12,经费235万元,负责人。
3. 国际科技合作与交流专项,“天然β-胡萝卜素***”(2014DFR30840),经费330万,2014-2017,负责人。
4. 山东省重点研发计划项目(医用食品专项),“用于孕期营养补充的固态特医食品制备关键技术及产品研发”(2017YYSP032),2017-2019,经费80万,负责人。
5. 山东省自主创新及成果转化专项“创新药物的早期成药与安全性评价关键技术的建立与应用” (2014ZZCX02105),子课题:50万,2014.1-2016.12,负责人。
   
    主要奖励(近五年)
1.“基于斑马鱼模型的中药心血管活性评价技术与应用”(首位)获得2016年度中华中医药学会科技进步二等奖。
2.“基于斑马鱼模型的中药心血管活性评价技术与应用”(首位)获2015年度山东省科技进步二等奖。
 

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